CS189 Spring 2026 Lec 25–27: AI for Protein Engineering, Agents and Environments, and Where to Go Next
The last three lectures take the semester's tools to two frontiers. Lec 25 is about proteins: AlphaFold2 cracked sequence-to-structure, but the real engineering bottleneck is predicting which sequence has the function you want, and design means acting as your own model's adversary in a discrete space of size 20^L. The slides reduce conditional generation p(x|y) to three statistically correct routes, all of which come back to Bayes' rule. Lec 26 was an online guest lecture with no public materials. Lec 27 defines an agent (an LLM in a loop, using tools, deciding its next step) and argues that data is being replaced by environments: Docker + task + verifier, used for SFT, RL (RLVR, GRPO), or weight-free GEPA. For final-exam practice, use the Fall 2025 and Spring 2025 finals with solutions; the Spring 2026 final is not published.